CHM 132 SU18 17 Homework 17.53 ch the words in the left column to the appropriat
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CHM 132 SU18 17 Homework 17.53 ch the words in the left column to the appropriate blanks in the sentences on the right. Make certain each sentence is complete before submi Reset Help 5-carbon Nucleoside analogs such as are similar to the nucleosides required to make viral DNA When they are incorporated into viral DNA, the lack of a group on the n the prevents the formation of the bonds and sugar-phosphate 3'-carborn hydroxyl stops the of the virus PKU reverse transcription replication AZT phosphate RequestAnswer MacBook Air FI F2 F3 F4Explanation / Answer
Ans. #1. Nucleoside analogs such as AZT are similar to nucleosides required to make viral DNA in reverse transcription. When they are incorporated into viral DNA, the lack of a hydroxyl group on the 3’-carbon in the base prevents the formation of the sugar-phosphate bonds and stops the replication of virus.
# AZT, a nucleoside analog, acts as inhibitor of viral reverse transcriptase.
# The 3’-end of AZT lacks a –OH group, but instead has an azide (N3) group. Absence of 3’-OH group in AZT does not mediate the formation of subsequent sugar-phosphate bond (sugar-phosphate) bond with the next coming nucleotide. Inhibition of reverse transcription further inhibits viral replication.
#2. Protease inhibitors stop the production of proteins needed for viral replication.
Viral protease cleaves precursor viral proteins into smaller, functional fragments which mediate the catalytic activities for viral replication as well as required for the assembly of viral particles.
# The protease inhibitors (drugs) inhibit viral protease, thus also inhibit the production of (functional) proteins from their precursor molecules. Lack o functional viral proteins further inhibits assembly and replication of viral particles.
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