Which of the following statementscorrectly describes why a series of closely spa
ID: 3035 • Letter: W
Question
Which of the following statementscorrectly describes why a series of closely spaced actionpotentials causes a sustained contraction rather than a series ofclosely spaced twitches?Ca2+ ions are released quickly fromtroponin, keeping the Ca2+ concentration in the cytosolhigh between closely spaced action potentials. Release of Ca2+ from thesarcoplasmic reticulum through channels is slow compared to theuptake of Ca2+ into the SR via ATP-dependent pumps,resulting in Ca2+ slowly trickling into the sarcomeresbetween closely spaced action potentials. When a series of action potentials is closelyspaced, there is not sufficient time for Ca2+ uptakeinto the sarcoplasmic reticulum between action potentials, andCa2+ remains bound to troponin throughout theseries. Fewer Ca2+ ions are released fromthe sarcoplasmic reticulum as a result of several closely spacedaction potentials than as a result of a single actionpotential. Which of the following statementscorrectly describes why a series of closely spaced actionpotentials causes a sustained contraction rather than a series ofclosely spaced twitches?
Ca2+ ions are released quickly fromtroponin, keeping the Ca2+ concentration in the cytosolhigh between closely spaced action potentials. Release of Ca2+ from thesarcoplasmic reticulum through channels is slow compared to theuptake of Ca2+ into the SR via ATP-dependent pumps,resulting in Ca2+ slowly trickling into the sarcomeresbetween closely spaced action potentials. When a series of action potentials is closelyspaced, there is not sufficient time for Ca2+ uptakeinto the sarcoplasmic reticulum between action potentials, andCa2+ remains bound to troponin throughout theseries. Fewer Ca2+ ions are released fromthe sarcoplasmic reticulum as a result of several closely spacedaction potentials than as a result of a single actionpotential.
Explanation / Answer
When a series of action potentials is closelyspaced, there is not sufficient time for Ca2+ uptakeinto the sarcoplasmic reticulum between action potentials, andCa2+ remains bound to troponin throughout theseries.
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