ATSAAGYDEWEGGRVIID ELDIGAV uman: ATSAAGWDEWEGGKVLIHLDGKLONRGALL ELDIGAV Chimpanz

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ATSAAGYDEWEGGRVIID ELDIGAV uman: ATSAAGWDEWEGGKVLIHLDGKLONRGALL ELDIGAV Chimpanzee: ATSAAGWDEWEGGKILIHILDGKLQNRGALL ELDIGAV Dashes indicate a deletion-the residues are missing in that sequence.) What is the most likely sequence of the protein present in the last common ancestor of chimpanzees and humans? 15. Finding Disease Genes You are a gene hunter, try- ing to find the genetic basis for a rare inherited disease. Examination of six pedigrees of families affected by the dis- ease provides inconsistent results. For two of the families, the disease is co-inherited with markers on chromosome 7. For the other four families, the disease is co-inherited with mark- ers on chromosome 12. Explain how this might occur. Data Analysis Problem 16. HincII: The First Restriction Endonuclease Discovery of the first restriction endonuclease to be of practical use was reported in two papers published in 1970. In the first paper Smith and Wilcox described the isolation of an enzyme that cleaved double-stranded DNA. They initially demonstrated the enzyme's nuclease activity hy measuring the decrease in

Explanation / Answer

15. Finding the disease: generally if we do not know what is the cause of a disease or if polygenic we use linkage analysis of genes .

There may be some allelic association between these genes . The two loci one on chromosome 7 and another on 12 are said to be associated only when these are independent of one another.

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