A researcher proposes to develop a vaccine against Hepatitis E as part of an ini

Question

A researcher proposes to develop a vaccine against Hepatitis E as part of an initiative to find a cure for liver cancer and is severely disappointed upon learning that the proposal has not been selected for funding. What is most likely a reason that the proposal was unsuccessful? Select one: a. Hepatitis E virus requires Hepatitis B virus for replication and thus proposing to only develop a vaccine against Hepatitis E virus cannot work. x b. Liver carcinoma is only caused by toxins and heavy drinking. c. Hepatitis E virus is self limiting and does not cause liver cancer. d. Hepatitis E does not affect humans. e. None of the choices.

Explanation / Answer

A) Hepatitis E do not require Hepatitis B to replicate. So, it is not acceptable. Hepatitis E is the cause of acute hepatitis worldwide. A recombinant Hepatitis E vaccine, HEV239 has been linched in China for immunized adult of 16yrs . The vaccine antigen contain pORF2 aa 368-606 of the HEV genotype 1 introduce in E. Coli.

Pathogenesis :HEV1, HEV2 infect human. And HEV3, HEV4 infect animals.

It is an enterically transmitted infection which is self-limiting . It is spread by faecal contaminated water in endemic areas or through consumption of under cooked meat. HEV infect liver cause sweeling, but patients well after few months. Usually not cause long term illness, liver damage like conditions .

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