. Amplification cascades, such as the one involved in blood clotting, are import

ID: 302246 • Letter: #

Question

. Amplification cascades, such as the one involved in blood clotting, are important in a

number of regulatory processes. The figure shows a hypothetical cascade involving

conversions between inactive and active forms of enzymes. Active enzyme A serves as

a catalyst for the activation of enzyme B. Active B in turn activates C, and so forth.

Assume that each enzyme in the pathway has a turnover number of 103. How many

molecules of enzyme D will be activated per unit time when one molecule of active

enzyme A is produced per unit time?

A Active

B Inactive ? B Active

C Inactive ? C Active

D Inactive ? D Active

The turnover number is the maximum amount of substrate that can be converted to product per enzyme per unit of time.

Only one molecule of enzyme D will be activated per unit time when one molecule of active enzyme A is produced

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