1)Which of the following will be affected in an opposite manner (inhibited by on
ID: 301997 • Letter: 1
Question
1)Which of the following will be affected in an opposite manner (inhibited by one and stimulated by the other) by cAMP-dependent protein kinase and AMP-activated protein kinase? Select all that apply
Phosphofructokinase-2 in ischemic heart
Lipolysis in adipose tissue
Glycogenesis in skeletal muscle
Glycogenolysis in liver
Cholesterol biosynthesis in liver
Gluconeogenesis in liver
Glucose uptake via GLUT 4 transporters
1)Which of the following will be activated by phosphorylation of key enzymes by protein kinase A (cAMP dependent protein kinase? (select all that apply)
Gluconeogenesis in liver
Glucose uptake via GLUT 4 transporters
Glycogenolysis in liver
Glycogenesis in skeletal muscle
Cholesterol biosynthesis in liver
Phosphofructokinase-2 in liver
Lipolysis in adipose tissue
3)Which of the following are treatments are currently widely used for a number of inborn errors of metabolism in humans? (select all that apply)
Ex vivo gene replacement
Infusion with stem and or progenitor cells
In vivo gene replacement using CRISPR-Cas9 modified cells
Oxygen transplantation
Use of RNA interference
Cofactor administration
Dietary manipulation
3)Match the pathway with its most highly regulated enzyme.
Fructose 1,6 biphosphate phosphatase
Glucose-6-phosphate dehydrogenase
Glycogen synthase
Phosphofructokinase 1
Acetyl CoA carboxylase
Carbamoyl phosphate synthetase
A.Glycogenesis
B. Glucogenesis
C.Urea cycle
D.Fatty acid synthesis
E.Glycolysis
F.Pentose phosphate pathway
4)Which of the following are DNA repair processes which are required to make the required gene edits after use of one of the gene editing systems? (select all that apply)
Alkytransferase catalyzed direct repair
Homologus recombination
Base excision repair
Nonhomologous end joining repair
Nucleotide excision repair
Explanation / Answer
2). Activated by phosphorylation of key enzymes of protein kinase A - Glycogenolysis in liver
Glucose uptake via GLUT 4 transporters
Phosphofructokinase kinase 2 in liver
Gluconeogenesis in liver
3). Ex vivo gene replacement
Dietary manipulation
In vivo gene replacement using CRISPR-CAS 9 modified cells
Oxygen transplantation
Cofactor administration
Infusion with stem or progenitor cells
4). Glycogenesis - Glycogen synthase
Glucogenesis - Fructose 1,6 biphosphate phosphatase
Urea cycle - Carbamoyl phosphate synthetase
Fatty acid synthesis - Acetyl co A carboxylase
Glycolysis - Phosphofructokinase - 1
Pentose phosphate pathway - Glucose 6 phosphate dehydrogenase
5). Homologous recombination
Base excision repair
Nucleotide excision repair
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