Shown below is the proposed model for how a portion of the hemoglobin structure

Question

Shown below is the proposed model for how a portion of the hemoglobin structure is thought to change in the transition between the oxy- (top) to deoxy- (bottom) conformations for mutant Hb Barcelona, which has a mutated beta subunit with an Asp94-> His94 amino acid substitution Proposed structural transition between oxy- (top) to deoxy- (bottom) Hb Barcelona HIS 94 LYS 40 GLU 90 O HIS 146 OXYHE MOGLOBIN BARCELONA HIS 94 LU 90 HIS 146 YS 40 DEOXYHE MOGLOBIN BARCELONA Calculate the estimated fractional difference in Bohr protons for the transitions between the two conformations of hemoglobin. Assume that any ionizable residue in these figures is directly exposed to an aqueous environment at pH 7.0 unless it has formed a salt bridge with another group in the molecule The fractional Bohr proton difference -deoxy-Hb Barcelona minus oxy-Hb Barcelona - approximately equals

Explanation / Answer

The fractional bohr proton difference at pH < /= 7 is directly proportional to the number of heme oxidised.

Related Questions

Navigate

• Browse (All)
• Browse S
• Subjects

---

---

Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.