You have identified a mutation that is associated with ADHD and have found it to

Question

You have identified a mutation that is associated with ADHD and have found it to be caused by a point mutation in Cu/Zn SOD. The disease is inherited in an autosomal manner. Two hypothesis have been proposed to explain the role of the gene in the disorder. A) SOD mutants is nullomorphic therby resulting in increased free radical damage ultimately resulting in tissue damage and disorder. B) The mutation is neomorphic resulting resulting in protein aggregation which ultimately results in cell death and the disorder. Answer the following; If an addition of an extra Cu/Zn SOD gene rescues the phenotype which hypothesis would be supported? If addition of an extra mutant copy of of the mutant gene exacerbated the phenotype which hypothesis would be supported? Justify your answers. If you knocked down the activity of the wild type SOD in an otherwise wildtype background what would be the predicted outcome if hypothesis A was correct; if hypothesis B was correct? Describe how would you carry out the 3 experiments in a mouse system.

Explanation / Answer

tell me the pedigree plz

Related Questions

Navigate

• Browse (All)
• Browse Y
• Subjects

---

---

Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.