1. Could cancer cells be selectively targeted by using antibodies recognizing a
ID: 2948789 • Letter: 1
Question
1. Could cancer cells be selectively targeted by using antibodies recognizing a tumor-specific protein marker? Researchers grafted human cancerous cells onto 20 healthy adult mice and then randomly assigned 10 of these mice to be treated with tumor-specific antibodies. They found that only 1 of the 10 mice treated with antibodies developed metastases, whereas all 10 of the 10 mice in the control group developed metastases.
We want to compare the proportions of mice developing metastases under the two conditions. Here, a large-sample significance test is
appropriate because the study was randomized.
not appropriate because the experiment is not double-blind.
not appropriate because the respective counts of successes and failures are not large enough.
D. appropriate because a total of 20 mice is large enough for any inference.
Refer to question number 6.
A plus-four 90% confidence interval for pcontrol - ptreatment (the difference in the proportions that develop metastases) is
0.53 to 0.97.
0.74 to 1.05.
0.17 to 0.92.
0.49 to 1.01.
A.appropriate because the study was randomized.
B.not appropriate because the experiment is not double-blind.
C.not appropriate because the respective counts of successes and failures are not large enough.
D. appropriate because a total of 20 mice is large enough for any inference.
Refer to question number 6.
A plus-four 90% confidence interval for pcontrol - ptreatment (the difference in the proportions that develop metastases) is
A.0.53 to 0.97.
B.0.74 to 1.05.
C.0.17 to 0.92.
D.0.49 to 1.01.
Explanation / Answer
Although the study was randomized, the number of success in the first case is only 1 which shows that n1p1 = 1 which is very low to perform the test. Therefore C is the correct answer here which states that the respective counts of successes and failures are not large enough.
Related Questions
Navigate
Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.