Problems 8-10 - Pedigree analysis. The pedigree shows the inheritance of a very

Question

Problems 8-10 - Pedigree analysis. The pedigree shows the inheritance of a very rare, completely penetrant autosomal recessive disorder. Note that the couple in generation IV are currently expecting their first child (indicated by the "") 8) What is the probability the child will be affected by the disorder? 9) What is the probability the child will be a carrier (i.e., heterozygous for the causative mutation)? wild-type)? are multiple routes that can produce the indicated outcomes in problems 9 and 10.) 10) What is the probability the child will be neither affected nor a carrier (i.e., that he/she will be homozygous Hints: Because there are only 3 possible genotypes, your 3 probabilities should add up to 1. Also note that there

Explanation / Answer

Answer 8:

The probability that the child in the fourth generation will be affected by autosomal recessive disorder is 25% only.

Answer 9: The probability for heterozygosity will be 50%.

Answer 10: The probabililty for not being affected by the disease is 75%.

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