1. Which of the following is not a molecule that mediates direct cell-cell inter

Question

1. Which of the following is not a molecule that mediates direct cell-cell interactions? A: Integrin B: Cadherin C: Selectin D: Fribonectin 2. Which of the following is a function of cadherins? A: A change in the type of cadherin a cell expresses can result in the transition of one cell type to another during development B: Cadherin can interact with selectin and link different types of cells into a tissue C: The cadherin levels in c C: The cadherin levels in cancer cell may be upregulated to allow cancer cells to migrate easily D: Cadherins are anchored to actin flaments in an adherins junction, so cadherins can from one cell to another

Explanation / Answer

1. Answer: Option D is correct.

Explanation: Cell adhesion molecules (CAM): Selectins, Integrins, and Cadherins

Fibronectin is a component of extracellular matrix. It is a glycoprotein (MW = 440 kDa). It binds to integrins, collagen, and fibrin.

2. Answer: Option C is correct.

Explanation: Cadherins = Calcium-dependent adhesion molecules. They are involved in the formation of adherens junctions. They are type-I membrane proteins and are dependent on calcium ions for their function. During development, cadherins are responsible for cellular migration and separation of different tissue layers. In many cancer cells, cadherins are overexpressed to allow rapid migration of cancer cells (Promotion of metastasis).

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