Answer a-e please Referring to the graph below, indicate: A) the K D of each of
ID: 279739 • Letter: A
Question
Answer a-e please
Referring to the graph below, indicate:
A) the KD of each of the 2 hormones (a vs b).
B)which hormone binds to the receptors more tightly ( a vs b)?
C)which hormone is stronger or more potent (a vs b)?
D) If hormone b is considered the agonist, would hormone a be a antagonist, superantagonist or partial agonist?
E) which hormone binds more receptors (a vs b)?
5. Referring to the graph below, indicate (A) the Ko of each of the 2 hormones (a vs b). (B) which hormone binds to receptors more tightly (a es b)? (C) which hormone is stronger or more potent (a vs. b) 7 (D) If hormone b is considered the agonist, would hormone superagonist or partial agonist? (E) which hormone binds more receptors (a vs b)? a be an antagonist, Co l,a0Explanation / Answer
A) KD is the dissociation constant which defines that half of the receptors are bound to hormone and half are free.
It is an important characteristic that shows the affinity of the hormone to the receptor.
For hormone a, 50% bound at concentration 10, KD= 10
And for hormone b, 50% bound at concentration 100, KD= 100
B) hormone a has more ability to bind tightly with the receptors since it represent a full agonist according to its position in graph. When present in an adequate concentration, a full agonist activates the receptors maximally on binding to them and consequently produces the maximal biological response.
C) a is stronger and potent than b as the position in graph shows. At a less concentration of 10, 50% of hormone a bound with receptors.
D) Even if hormone b is an agonist, hormone a can not be an antagonist. For an antagonist the interaction sta rts at higher concentration than an agonist does. Here hormone a starts interaction at lower concentration than hormone b. This is similar to a partial agonist does. But the upper part of plot for hormone a does not behave as for a partial agonist for which it is flat.
E) hormone a binds more receptors. From the graph hormone-receptor interaction is more for hormone a.
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