Question : Into a flask containing the same starting solution from the previous

Question

Question : Into a flask containing the same starting solution from the previous question (containing cellular concentrations of G6P and F6P), you add the enzyme Glucose 6-phosphate isomerase. How will the concentration of molecules in this solution change over time? Drag and drop the correct symbols next to the correct molecule. Note: each answer may be used once, more than once or not at all.

Previous given question: ( I answered the same for both box and it was correct)

The reaction in which glucose 6-phosphate (G6P) is converted to fructose 6-phosphate (F6P) is an example of an isomerization reaction. Notice that both molecules have the molecular formula C6H13O9P. The isomerization catalyzed by glucose 6-phosphate isomerase is:

This is a reversible reaction in cells, with a moderately negative ?G, but a very high activation energy. If you have a flask that contains a solution containing cellular concentrations of G6P and F6P, but no enzyme, how will the concentration of each molecule change over time? Drag and drop the correct symbols next to the correct molecule. Note: each answer may be used once, more than once or not at all.

Explanation / Answer

We know that the reaction in which glucose 6-phosphate (G6P) is converted to fructose 6-phosphate (F6P) is a reversible reaction in cells, with a moderately negative ?G, but a very high activation energy. Since the reaction has moderately negative ?G so its thermodynamically favored but since the activation energy of the reaction is very high, therefore, the reaction does not occur spontaneously in the cell. This is the reason why your first answer that is the concentrations of both G6P and F6P will remain the same is correct.

Now when you add the enzyme Glucose 6-phosphate isomerase, it will lower the activation energy of the reaction and then the reaction will take place in forward direction i.e. G6P will convert into F6P. Therefore, your answers will be – the concentration of G6P will decrease and the concentration of F6P will increase.

Thanks!

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