Suppose both a group of people with a heritable disease and a control group with

Question

Suppose both a group of people with a heritable disease and a control group without the disease are tested for their genotype at the disease locus and their genotype for a large number of different SNPs (single-nucleotide polymorphisms). The disease locus is later determined to be in linkage disequilibrium with one SNP in particular. Select the answers below that describe the two loci in linkage disequilibrium. At what frequency are the disease allele and a particular nucleotide variant of the SNP found together, compared to the frequency expected by chance? O higher O consistent lower When did the mutation responsible for the disease arise on the chromosome, compared to the SNP? O before O after O concurrently

Explanation / Answer

Higher:

The frequency of the disease allele and particular nucleotide variant of SNP found together will be higher than compared to the frequency of expected.

linkage disequilibrium is a non -random association of alleles in which the probability of occurring them together will be higher than the independent assortment.

Concurrently:

The mutation responsible for disease arise on the chromosome may be occurring concurrently with the SNP so that co-incidence of both will be at higher proportion, otherwise mutant and SNP phenotype may be randomly distributed (by chance).

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