It’s a immunology problem: Some autoimmune diseases are characterized by the pro
ID: 278111 • Letter: I
Question
It’s a immunology problem: Some autoimmune diseases are characterized by the production of antibodies of IgG isotype that are specific for DNA. Knowing that B cells need T cell help for proper activation and isotype class switching and that DNA cannot be presented on MHCs to T cells, how would you explain this phenomenon? It’s a immunology problem: Some autoimmune diseases are characterized by the production of antibodies of IgG isotype that are specific for DNA. Knowing that B cells need T cell help for proper activation and isotype class switching and that DNA cannot be presented on MHCs to T cells, how would you explain this phenomenon? It’s a immunology problem:Explanation / Answer
One of the autommmune disorders in which there are production of antibodies aainst cell nucleus proteins and DNA is Systemic Lupus Erythematosus (SLE). Over here, high number of polyclonal B cells are found and they have their population shift more towards immature B cells and do not get cleared in the bone marrow even if they attack self antigens ( the genetic cause of SLE is still under progress). The immature B lymphocytes will produce antibodies against self cell nucleus proteins( histones/chromatin etc) and DNA. T cells, that regulate B-cell responses have defects in processes such as adhesion, signaling,co-stimulation, gene transcription, and alternative splicing. C3 levels in the complementary system is also low for these patients. Errors in all important checkpoint processes lead to SLE although they are considered to be multifactorial in nature with respect to genes.
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