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What causes synaptic facilitation? Release of greater than usual number of synap

ID: 277429 • Letter: W

Question

What causes synaptic facilitation?

Release of greater than usual number of synaptic vesicles

Activation of synaptotagmin by means of phosphorylation

Buildup of Ca2+ in the presynaptic terminal

Release of synaptic vesicles loaded with extra neurotransmitter

Which process differentiates long-term from short-term sensitization?

Changes in the synapses between the sensory and motor neurons

Synaptic transmission between the facilitatory and sensory neurons

Changes in gene expression

Production of cAMP

Which condition(s) must be met to induce LTP?

Glutamate must be released from the presynaptic terminal

Glutamate must open the postsynaptic AMPA receptors

The postsynaptic membrane must be depolarized for a period of time

Mg2+ block must be expelled from NMDA receptors to allow Ca2+ influx

All of the above

Which observation would demonstrate the spike timing-dependent plasticity of synapses?

Whether or not LTP occurs is dependent on the specific temporal pattern of action potentials.

Switching the relative timing of action potential and EPSP by as little as 20 ms can switch the response from LTD to LTP, or vice-versa.

LTP occurs whenever an action potential precedes an EPSP.

LTD occurs whenever an action potential follows an EPSP.

How would an increase in external Ca2+ concentration affect synaptic depression?

It would increase the rate of depression.

It would have no effect on depression

It would reduce the rate of depression.

It would decrease the rate of neurotransmitter release and induce depression.

LTP represents a lasting increase in the size of EPSP

following a high-frequency train of stimuli.

that is restricted to the cortex

following a low-frequency train of stimuli

following a single stimulus

Release of greater than usual number of synaptic vesicles

Activation of synaptotagmin by means of phosphorylation

Buildup of Ca2+ in the presynaptic terminal

Release of synaptic vesicles loaded with extra neurotransmitter

Which process differentiates long-term from short-term sensitization?

Changes in the synapses between the sensory and motor neurons

Synaptic transmission between the facilitatory and sensory neurons

Changes in gene expression

Production of cAMP

Which condition(s) must be met to induce LTP?

Glutamate must be released from the presynaptic terminal

Glutamate must open the postsynaptic AMPA receptors

The postsynaptic membrane must be depolarized for a period of time

Mg2+ block must be expelled from NMDA receptors to allow Ca2+ influx

All of the above

Which observation would demonstrate the spike timing-dependent plasticity of synapses?

Whether or not LTP occurs is dependent on the specific temporal pattern of action potentials.

Switching the relative timing of action potential and EPSP by as little as 20 ms can switch the response from LTD to LTP, or vice-versa.

LTP occurs whenever an action potential precedes an EPSP.

LTD occurs whenever an action potential follows an EPSP.

How would an increase in external Ca2+ concentration affect synaptic depression?

It would increase the rate of depression.

It would have no effect on depression

It would reduce the rate of depression.

It would decrease the rate of neurotransmitter release and induce depression.

LTP represents a lasting increase in the size of EPSP

following a high-frequency train of stimuli.

that is restricted to the cortex

following a low-frequency train of stimuli

following a single stimulus

Explanation / Answer

Ans 1 : Build up of Ca2+ in the presynaptic terminal.

The synaptic facilitation occurs when the more than one action potentials reach the presynaptic terminal simultaneously. This causes an increase in the strength of stimulus at the terminal. More than the usual amount of neurotransmitter is released and the calcium ions are build up at the presynaptic terminal.

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