Panel A shows the initial crosses and representative chromosomes of animals in a
ID: 276600 • Letter: P
Question
Panel A shows the initial crosses and representative chromosomes of animals in a QTL mapping project. The black regions represent chromosome material from the largest purebred line and the white regions represent the other purebred line used in the experiment. Panels B, C, D and E show the karyotypes representative of the smallest and darkest animals from populations of mice that were created for QTL mapping Pure line A Pure line B ?8 IT The chromosomes in panels B-E represent the smallest and darkest animals from their respective populations. Which chromosomes are most likely to have genes that affect the two traits? Indicate with an S (for size loci) or P (pigment loci) on the chromosomes to the top right the potential location/s of all the potential QTLs. Explain your reasoning.Explanation / Answer
According to the information, two pure-breeding mice are crossed with each other to obtain a F1 population, all heterozygous. These F1 were selfed to obtain a F2 population. The genotype profile of these F2 individuals show that the trait for body size governed by gene S is largely localized on pair 1 of the chromosome. On the other hand, it also suggests that the gene for body color or pigementation governed by gene P is localized on pair 4. This is because the animal corresponding to the first panel of recombinants represents the smallest in size hence the fraction of S allele would be maximized on it. Similarly, the animal corresponding to the panel E is the darkest hence the allele for the P would be largely fractionized on it.
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