Do you think the total number of SNPs within protein coding exons is greater tha

Question

Do you think the total number of SNPs within protein coding exons is greater than or less than the total number of SNPs present at other genomic regions? What is the basis of your answer? Do you think the density of SNPs within protein coding exons is greater than or less than the density of SNPs at other genomic regions? What is the basis of your answer. What about recessive lethal mutations (ie, mutations that really break the machine"? Do you think the density of recessive lethal mutations would be higher within protein coding exons or at other genomic regions? What is the basis of your answer.

Explanation / Answer

Yes, total number of SNPs within protein coding exons is less than the total number of SNPs present at other genomic regions because the SNPS is something that represents difference in one single DNA building block. The SNPs rates are always higher within the non-coding region but its conversation is higher at the regulatory sites. The SNP rates are highest and conservation lowest at coding sequence which pertains to the exons.

The density of SNPs is not greater than density of SNPs in other genomic regions because the conservation might be higher but not the rates. As per the research it is found that the introns have 30% higher SNPs density as compared to the exons. They appear at higher rates in non-coding regions.

The density of the recessive lethal mutations is higher within protein coding exons because one single mutation or change in the nucleotide change can cause a whole new impact and difference.

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