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* Pedigree reference available upon request after assignment submission 1. (2 po

ID: 276192 • Letter: #

Question

* Pedigree reference available upon request after assignment submission 1. (2 points- 0.5 points each) Please specifically state what individual each symbol description designates in a pedigree a. Filled circle b. Filled square with a diagonal line c. Circle with a smaller filled circle inside d. Filled square with an arrow pointing to it 2. (4 points-1 point each) Please answer each question based on the pedigree below. a. (0.5 points) For the individuals IIl-5 and IIl-6 how many children did they have? b. (0.5 points) Which individuals are the children of the individuals in generation I (Be careful of your notation. (State generation then individual-ex. II-2 is individual 2 in generation 2)

Explanation / Answer

1) a: Filled circle: Female affected with trait understudy

b: Filled square with a diagonal line: Affected male, died either due to disease or other regions

c: a circle with a smaller filled circle inside: Carrier female ( who have generally have one mutant copy but no clinical symptoms but carry to the next generation)

d: Filled square with an arrow pointing to it: an Affected male who is propositus/proband/index patient (Propositus is the person from which the pedigree analysis started)