Proloabilitv 2 19. Sheala and Zoltan are thinking of having a child together, bu
ID: 276130 • Letter: P
Question
Proloabilitv 2 19. Sheala and Zoltan are thinking of having a child together, but they are worried. Both of them have siblings who died in their teens from a disease called cystic fibrosis, which is an autosomal (non-sex-linked) recessive disorder. Sheala also had a cousin who died at age 10 from Duchenne muscular dystrophy (DMD), a recessive X-linked disease. On top of all of this, both Sheala and Zoltan have thalassemia minor. Given this unfortunate genetic background, both prospective parents go for genetic testing, the results of which indicate that both are carriers for cystic fibrosis. In addition, Sheala is a carrier for DMD. (a) What is the probability that a child born to Sheala and Zoltan would have at least one of the three diseases, cystic fibrosis, DMD or thalassemia major? (b) Would your answer change if you knew the sex of the child? Explain in detail.Explanation / Answer
For the scenario a.
There is a 75% chance of the offspring tobe affected with thalassemia, 25% chance of Cystic fibrosis and 25% chance of DMD
Thalassemia minor is due to the condition (B/B<o/+>) or in short (B/b)
If we know the sex of the child then, if a boy is born then there is 50% chance of cystic fibrosis, while the probability of the other two remains the same.
B b B BB (Healthy) Bb ( th minor) b Bb (th minor) bb (th major)Related Questions
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