16. (2 points) A hypothetical scenario: some anti-retroviral drugs used to treat

Question

16. (2 points) A hypothetical scenario: some anti-retroviral drugs used to treat HIV infected patients have been clinically shown to cause type I diabetes in these patients upon long-term usage. It is suspec ine drugs might have a direct effect on the physiological function of the pancreas, particularly affecting selnuiroduction. Describe how you could examine the side effecet of the drugs on human panerentie ted that cells by using iPSCs technology. 7. (2 points) Assuming a family is discovered to have extremely high genetic disposition to develop cardiac hypertrophy, a disease manifested by enlarged heart cells. Describe how hypothetically you could use ? 'SC technologyto develop an nyitrocardiac y pertrophy cel model to screen for potential drugs that could alleviate the symptom

Explanation / Answer

16) By using induced pluripotent stem cells (iPSCs) technology we can generate in vitro functionally mature ??like cells from fibroblasts & can examine the insulin secretion ability in response of glucose. Thus we can effectively examine the side effects of the drugs.

17) Analysis of human diseased tissue is helpful for understanding the disease mechanisms, but due to extreme difficulty to obtain these cells through routine clinical procedure disease mechanism is poorly understood. Thus, iPSCs have a strong potential for use in cardiovascular disease modelling. By using iPSC technology we will be able to differentiate iPSCs into cardiomyocytes in vitro. Thus, it will enable us to understand the underlying disease mechanism & develop therapeutic agents.

Related Questions

Navigate

• Browse (All)
• Browse 1
• Subjects

---

---

Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.