5. Astrocytes often serve as support cells that provide fuel for the neurons. De

Question

5. Astrocytes often serve as support cells that provide fuel for the neurons. Describe briefly the processes carried out by astrocytes to feed the neurons. 6. What type of signaling molecules are serotonin, norepinephrine, and dopamine (is it a peptide, or steroid, etc)? Refer to our lecture on types of signaling molecules, please. 7. Please briefly describe the process of serotonin release and re-uptake. 8. The mechanism of action of citalopram is as an SSRI. How exactly does SSRI work? 9. How is citalopram metabolized in the liver? Which phase is the reaction catalyzed by MAO-A and MAO-B? Hint MAO stands for MonoAmine Oxidase enzyme. 10. As shown on the slides, does citalopram metabolism involve any phase II reaction for excretion out of our system? 11. What transporters in the blood brain barrier are responsible for citalopram transport? Based on what we have learned in this class, can you predict what type of transporters (passive, primary active, etc) these are? Please also state if ATP is needed in this transport system.

Explanation / Answer

5. Astrocytes store glycogen and can perform gluconeogenenesis. Thus it can supply glucose to the adjacent neurons during high glucose consumption and glucose shortage.

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