1. A comparison of 4O6Z and 1YAA shows that ________ linkage between a lysine re

Question

1. A comparison of 4O6Z and 1YAA shows that ________ linkage between a lysine residue and PLP.

Option A: both enzymes form an amine

Option B: only one enzyme forms an amine

Option C: only one enzyme forms an imine

Option D: both enzymes form an imine

2. Comparison of 4O6Z and 1YAA also demonstrates that the pyridine ring of PLP is planar, and atoms C5 and C6 of the cofactor interact with ________.

Option A: lysine via hydrogen bonds

Option B: aromatic amino acids via hydrogen bonds

Option C: aromatic amino acids via hydrophobic interactions

Option D: lysine via hydrophobic interactions

Explanation / Answer

1. Option A: both enzymes form an amine

This is correct as Enzyme 4O6Z forms L- serine and the enzyme 1YAA forms L-glutamate in the product of the reaction catalysed.

2. The C 5 of cofactors in both 4O6Z and 1YAA are attached : aromatic amino acids via via hydrophobic interactions. So option C is c orrect.

4O6Z the C5 interacts with Threonine and H6 with histidine. And in case of 1YAA it interacts with C5 interacts with Tryptophan and tyrosine while C6 interacts with Ligand Mae that is mallic acid. And there is no free OH in C 6 and C5 so interaction is hydrophobic.

Related Questions

Navigate

• Browse (All)
• Browse 1
• Subjects

Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.