(Please fill in the blank) Oleate is a C_______ fatty acid with one double bond

Question

(Please fill in the blank) Oleate is a C_______ fatty acid with one double bond between the _______and _________ carbons. The ? oxidation of a saturated fatty acid with an equivalent number of carbons would yield ______ ATP: ____ cycles of ? oxidation = _____ ATP; _____ acetyl-CoA yield ______ ATP via the citric acid cycle and oxidative phosphorylation; and ________ ATP are consumed in activating the fatty acid. During ? oxidation of oleate, the presence of the double bond allows the FADH2-generating acyl-CoA dehydrogenase step to be skipped, at a cost of _______ ATP equivalents. Therefore, the ATP yield from oleate is _______.

Explanation / Answer

Oleate is a C 18 (18 carbon-containing) fatty acid with one double bond between the 9th and 10th carbons( it could be denoted as 18:1; n-9. which represents the number of carbons in a fatty acid (18) and double bonds (1), and the position of the double bond (n-9)). The oxidation of a saturated fatty acid with an equal number of carbons would yield 146 ATP. in 8 cycles of beta oxidation= 40 ATP; 9 acetyl-CoA yeild 108 ATP via citric acid cycle and oxidative pospharilation, and 2 ATP consumed in activating the fatty acid. During beta-oxidation of oleate, the presence of the double bond allows FADH2-generating acyl-CoA dehydrogenage step to be skipped, at cost of 2 ATP equivalents. Therefore the ATP yield from oleate is 144.

Explanation: The beta-oxidation of fatty acids yield high energy in the form of ATP.  

If a fatty acid has N number of carbons, it produces N acetyl-CoA and (n-1) number of NADH2 and FADH2.

Acetyl-CoA on citric acid cycle produces 10 ATP and NADH2 and FADH2 yield 3 and 2 ATP's respectively.

If oleic acid( 18 carbon fatty acid with 1 double bond) is undergone 8 cycles beta-oxidation to produce 8NADH2 and 8 FADH2 which upon oxidative phosphorylation gives (8x3=24)+(8x2=16)=40 ATP. 9 acetyl CoA produced from beta-oxidation. acetyl CoA on citric acid cycle produce(9x12=108ATP).

108+ 24+ 16= 148

If 2 ATP consumed during activation of Fatty acid into Faty-acyl-CoA then the energy yield is 148-2=146 ATP

Oleic acid has one unsaturation then 1 FADH2 is reduced then it become= 144.

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