1. When the blood glucose concentration is high, the level of cAMP in the liver
ID: 275432 • Letter: 1
Question
1. When the blood glucose concentration is high, the level of cAMP in the liver decreases and glycolytic flux increases. Which biochemical steps occur under this condition?
I. Protein kinase A is activated.
II. Protein kinase A is not activated.
III. Phosphofructokinase-2 is activated via phosphorylation by protein kinase A.
IV. Phosphofructokinase-2 is activated due to the lack of phosphorylation by protein kinase A.
V. Fructose-2,6-bisphosphatase is activated via phosphorylation by protein kinase A.
VI. Fructose-2,6-bisphosphatase is activated due to the lack of phosphorylation by protein kinase A.
VII. Phosphofructokinase-1 is activated by fructose-2,6-bisphosphate.
VIII. Phosphofructokinase-1 is inhibited by fructose-2,6-bisphosphate.
IX. Fructose-1,6-bisphosphatase is activated by fructose-2,6-bisphosphate.
X. Fructose-1,6-bisphosphatase is inhibited by fructose-2,6-bisphosphate.
2. After glucagon stimulates glucose production via glycogenolysis and/or gluconeogenesis in a liver cell, which steps are required to transport glucose to other cells in the body?
a. glucose-6-phosphate is converted to glucose by GLUT-1
b. glucose cannot leave the liver cell
c. glucose is transported to other cells by the carrier protein GLUT-1
d. glucose exits the liver cell via GLUT-1 and enters the bloodstream
Explanation / Answer
1.
II. Protein kinase A is not activated.
IV. Phosphofructokinase-2 is activated due to the lack of phosphorylation by protein kinase A.
VII. Phosphofructokinase-1 is activated by fructose-2,6-bisphosphate.
2.
None of the given options are correct.
Glucose is transported from liver cell to bloodstream by GLUT-2 (a transmembrane carrier protein).
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