as ine Exam I- Requires Respondus LockDown Browser : Jun 3 at 4:54pm z Instructi

Question

as ine Exam I- Requires Respondus LockDown Browser : Jun 3 at 4:54pm z Instructions Question 27 2 pt Tay-Sachs disease is a heritable neurodegenerative disorder caused by the destruction of neurons in the brain and spinal cord. Affected individuals have a mutation in the HEXA gene which codes for an enzyme that breaks down toxic compounds. The mutation is an insertion of 4 additional DNA nucleotides in the HEXA gene, resulting in a longer amino acid sequence and also changes the type of arnino acids encoded. Which level of protein structure is the first level of structure affected in Tay-Sachs disease? Primary O Secondary O Tertiary Quaternary Next 4 Previous 8 5 3

Explanation / Answer

Since the mutation introduces 4 nucleotides in the middle of the gene and an aminoacid is each coded by 3 nucleotide, there will be a frame shift in which aminoacids are being coded so that would result in an entirely different aminoacid sequence.

So the answer should be A) Primary structure as the sequence of the protein itself is changed altogether of the region that is coded after the mutation.

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