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PLEASE ANSWER ALL PARTS 1) Select evidence that suggests addiction has a genetic

ID: 274798 • Letter: P

Question

PLEASE ANSWER ALL PARTS

1) Select evidence that suggests addiction has a genetic component. Check all that apply.

Check All That Apply

There is a two- to threefold increase in risk of addiction for adopted individuals with one affected biological parent.There is a two- to threefold increase in risk of addiction for adopted individuals with one affected biological parent.

People homozygous for a certain allele of the dopamine D(2) receptor gene variant are over-represented among those with alcoholism.People homozygous for a certain allele of the dopamine D(2) receptor gene variant are over-represented among those with alcoholism.

THC binds to receptors on human neurons.THC binds to receptors on human neurons.

Certain variants within the nicotinic receptor lead to a desire to continue smoking after the first cigarette.

2) Mood disorders are based in part on genetic factors. Choose the best term to complete each of the following sentences about mood disorders.
1. In the mood disorder called  (Click to select)  major depressive disorder  bipolar disorder  hypomania  , people experience periods of mania.

2. Selecting antidepressants based on genotype is an example of a form of genetic testing called  (Click to select)  pharmacogenetics  exome sequencing  trio analysis  I.Q. testing  .

3. Bipolar disorder with  (Click to select)  mental retardation  muscle dysmorphia  schizophrenia  hypomania  may appear to be depression.

4. Bipolar disorder affects approximately  (Click to select)  20.6  8.6  32.6  2.6  percent of the population.

5. Deficiency of the neurotransmitter  (Click to select)  acetylcholine  serotonin  norepinephrine  dopamine  is considered a likely cause of depression.

3) What type of treatment might be useful in cases of autism involving mutations in neurexins and neuroligins?

Multiple Choice

Treatments that draw neurons closer together

Treatments that prevent synaptic pruning

Treatments that decrease the interaction between two neurons

Treatments that increase the amount of serotonin in synapses

4) A doctor performs exome sequencing on a number of autistic patients from different families. He uses a database to compare their genomes to those of healthy individuals. What type of exome sequencing is he performing?

Multiple Choice

Twin studies

Trio analysis

Recessive analysis

Multiple unrelated affected subjects

Explanation / Answer

1. Both the options are correct:

People homozygous for a certain allele of the dopamine D(2) receptor gene variant are over-represented among those with alcoholism and

THC binds to receptors on human neurons. Certain variants within the nicotinic receptor lead to a desire to continue smoking after the first cigarette.

2).

a. During hypomania, the patient generally experiences periods of heightened mania or depression.

b. Exome sequencing trio analysis, is a form of treatment where depending on the patients, the tests and medicines are prescribed to give better outcomes and avoid major economic costs.

c. Bipolar disorder with hypomania might appear as depression.

d. Bipolar disorder affects around 2.6% of the population.

e. Deficiency of dopamine might lead to depression like symptoms.

3. Treatments that increase serotonin at the synapses might help.

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