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20) Gene X is regulated by a Ca++ responsive transcription factor. Under low lev

ID: 274697 • Letter: 2

Question

20) Gene X is regulated by a Ca++ responsive transcription factor. Under low levels of Cat+ the transcription factor is localized to the cytoplasm and is inactive. Under high Ca++ concentrations, the transcription factor translocates to the nucleus and activates gene X through its C-terminal TAD. For each of the mutants analyzed below, indicate which domain of the transcription factor is most likely mutated - Ca + Ca Sample Localization Bound to DNA Gene X activity Localization Bound to ONA Gene X activity Mut Domain None Yes Yes No No Cytoplasm WT Mut1 Mut2 Mut3 No No No No Cytoplasm Cytoplasm Low Low Low Nucleus Nucleus Low Low Low lasm Nucleus

Explanation / Answer

According to the data given,