11) A mutation occurred in the box marked v. as indicated below with the mutated

Q: 11) A mutation occurred in the box marked v. as indicated below with the mutated

11) As the mutated cell produce significantly less amount of proteins, most likely mutation is of nonsense type. In this type of mutation new codon is a stop codon which prematurely stops the translation & thus less amount of protein is produced.

ID: 274691 • Letter: 1

Question

11) A mutation occurred in the box marked v. as indicated below with the mutated base underlined. While the protein you isolated from cells is the correct size and appears to function normally, there is significantly less protein in mutant cells compared to the WT. What is the most likely effect of the mutation? v. 5' CGTGCG 3 3 GCACGC 5 12) The cytosine within box vi has been modified by methylation producing 5-methylcytosine. Subsequently, 5-meC was deaminated. Assuming the cell's repair system missed the error, what effect will the mutation have on the encoded protein? What affect will it have after the next round of replication?

Explanation / Answer

11) As the mutated cell produce significantly less amount of proteins, most likely mutation is of nonsense type. In this type of mutation new codon is a stop codon which prematurely stops the translation & thus less amount of protein is produced.

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11) A mutation occurred in the box marked v. as indicated below with the mutated

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