salress both leM and leD molecules on its surface at the same time is made possi
ID: 274389 • Letter: S
Question
salress both leM and leD molecules on its surface at the same time is made possible by A) selective RNA splicing. B) allelic exclusion. Q isotype switching. Di simultancous recognition of two distinct antigens. 41. Dendritic cells A) Present antigen only via MHC II B) Present antigen via MHC I and II. O Carry antigen to the thymus. D) Present antigen only via MHC I TH cells A) Recognize MHC II using TCR and CD8 B) Recognize MHC II using TCR and CD4 Q Recognize MHC II using TCR and CD14. D) Recognize MHC I using TCR and CD4. a. Which of the following generally does not apply to bone marrow (a primary lymphoid organ) and secondary lymphoid organs? A) differentiation of lymphocytes. B) antigen-dependent response. Q cellular proliferation. D) cellular interaction. 44. T cells deliver help to B cells using A) Cytokines and CD8. D) Cytokines and CD40L 45. Primary lymphoid organs B) Selectins and CD8. c Kinetoblasts and complement. A) Are where B lymphocytes make BCRs. B) Are where T lymphocytes make TCRs. c) Are where secondary innate immune responses occur D) Both A and B.Explanation / Answer
40) The answer will be selective RNA splicing (Option A).
Explanation: Alternative splicing is the process through which single gene can encode multiple proteins. Simultaneous expression of IgM & IgD is possible by alternative splicing of primary RNA transcript 5'— VDJ— Cg— Cm— Cd— 3'.
41) The answer will be present antigen via MHC I & II (Option B).
Explanation: Dendritic cell is one of the professional antigen-presenting cells. T cells can only recognize & respond to antigens that is processed & presented by cells via carrier molecules like MHC molecules. It can't recognize or respond to free or soluble antigens. CD8+ cytotoxic T cells recognize antigens that are presented by MHC class I molecules & CD4+ helper T cells recognize antigens that are presented by MHC class II molecules. As dendritic cells are able to express both MHC I and MHC II molecules they present antigens to both cytotoxic & helper T cells.
42) The answer will be recognizing MHC II using TCR & CD4 (Option B).
Explanation: Signalling co-receptor CD4 on TH cells enhance its response. It helps to stabilize the weak T-cell receptor (TCR)-pMHC interactions (peptide–major histocompatibility) & ultimately enhancing the TCR signalling.
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