Question 5 What would happen to the (i) magnitude of the mitochondrial proton gr

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Question 5 What would happen to the (i) magnitude of the mitochondrial proton gradient, (ii) rate of mitochondrial oxygen consumption, and (iii) rate of acetyl-CoA oxidation in cells treated with the ATP synthase inhibitor oligomycin? Recall the hose analogy described in Mitochondrial Research Techniques.
A. (i) increase, (ii) increase, (iii) increase
B. i) increase, (ii)decrease, (iii) increase
C. i) decrease, (ii)decrease, (iii) decrease
D. i) decrease, (ii)increase, (iii) increase
E. i) increase, (ii) decrease, (iii) decrease
Question 6 Where might you expect to find mutations that lead to mitochondrial disease (i.e., diseases that are a consequence of mitochondrial dysfunction)?
A. Nuclear DNA
B. Mitochondrial DNA
C. Both
Question 7 1 point possible (graded) Which type(s) of mitochondrial diseases could potentially be prevented by 3-way in vitro fertilization?
A. Diseases that arise from mutations in the nuclear DNA
B. Diseases that arise from mutations in the mitochondrial DNA
C. Both
D. Neither
Question 8 1 point possible (graded) Which of these tissues are most likely to display significant defects in patients with a mitochondrial disease? (Select all that apply.)
A. Cartilage
B. Heart
C. Bone
D. Neural
E. Adipose
Question 9 0.0/2.0 points (graded) Barth Syndrome is characterized by dysfunctional mitochondria with a lower capacity to produce ATP. Barth syndrome patients experience difficulty walking and exercising. Why do Barth patients have these impairments? (Select all that apply.)
A. Because ATP is required for skeletal muscle contraction.
B. Because ATP is required for the pumping of blood by the heart.
C. Because ATP is required for the release of oxygen by red blood cells.
D. Because ATP is required for absorbing oxygen by red blood cells.
Question 10 0.0/2.0 points (graded) Bongkrekic acid is a mitochondrial toxin produced by bacteria in fermented coconuts. It blocks the inner membrane protein responsible for transporting ATP from the mitochondrial matrix to the cytosol. Bongkrekic acid also inhibits ADP import from the cytosol into the matrix for phosphorylation. Which of the following will occur in a cell exposed to bongkrekic acid? (Select all that apply.)
A. Most ATP in the cell will be produced by glycolysis because the mitochondria are inhibited.
B. The mitochondrial membrane potential will decrease due to decreased ETC proton pumping.
C. Respiration will decrease because the ATP synthase will lack ADP as the reactant.
D. Mitochondrial ATP levels will decrease.

Question 5 What would happen to the (i) magnitude of the mitochondrial proton gradient, (ii) rate of mitochondrial oxygen consumption, and (iii) rate of acetyl-CoA oxidation in cells treated with the ATP synthase inhibitor oligomycin? Recall the hose analogy described in Mitochondrial Research Techniques.
A. (i) increase, (ii) increase, (iii) increase
B. i) increase, (ii)decrease, (iii) increase
C. i) decrease, (ii)decrease, (iii) decrease
D. i) decrease, (ii)increase, (iii) increase
E. i) increase, (ii) decrease, (iii) decrease
Question 6 Where might you expect to find mutations that lead to mitochondrial disease (i.e., diseases that are a consequence of mitochondrial dysfunction)?
A. Nuclear DNA
B. Mitochondrial DNA
C. Both
Question 7 1 point possible (graded) Which type(s) of mitochondrial diseases could potentially be prevented by 3-way in vitro fertilization?
A. Diseases that arise from mutations in the nuclear DNA
B. Diseases that arise from mutations in the mitochondrial DNA
C. Both
D. Neither
Question 8 1 point possible (graded) Which of these tissues are most likely to display significant defects in patients with a mitochondrial disease? (Select all that apply.)
A. Cartilage
B. Heart
C. Bone
D. Neural
E. Adipose
Question 9 0.0/2.0 points (graded) Barth Syndrome is characterized by dysfunctional mitochondria with a lower capacity to produce ATP. Barth syndrome patients experience difficulty walking and exercising. Why do Barth patients have these impairments? (Select all that apply.)
A. Because ATP is required for skeletal muscle contraction.
B. Because ATP is required for the pumping of blood by the heart.
C. Because ATP is required for the release of oxygen by red blood cells.
D. Because ATP is required for absorbing oxygen by red blood cells.
Question 10 0.0/2.0 points (graded) Bongkrekic acid is a mitochondrial toxin produced by bacteria in fermented coconuts. It blocks the inner membrane protein responsible for transporting ATP from the mitochondrial matrix to the cytosol. Bongkrekic acid also inhibits ADP import from the cytosol into the matrix for phosphorylation. Which of the following will occur in a cell exposed to bongkrekic acid? (Select all that apply.)
A. Most ATP in the cell will be produced by glycolysis because the mitochondria are inhibited.
B. The mitochondrial membrane potential will decrease due to decreased ETC proton pumping.
C. Respiration will decrease because the ATP synthase will lack ADP as the reactant.
D. Mitochondrial ATP levels will decrease.

Question 5 What would happen to the (i) magnitude of the mitochondrial proton gradient, (ii) rate of mitochondrial oxygen consumption, and (iii) rate of acetyl-CoA oxidation in cells treated with the ATP synthase inhibitor oligomycin? Recall the hose analogy described in Mitochondrial Research Techniques.
A. (i) increase, (ii) increase, (iii) increase
B. i) increase, (ii)decrease, (iii) increase
C. i) decrease, (ii)decrease, (iii) decrease
D. i) decrease, (ii)increase, (iii) increase
E. i) increase, (ii) decrease, (iii) decrease
Question 6 Where might you expect to find mutations that lead to mitochondrial disease (i.e., diseases that are a consequence of mitochondrial dysfunction)?
A. Nuclear DNA
B. Mitochondrial DNA
C. Both
Question 7 1 point possible (graded) Which type(s) of mitochondrial diseases could potentially be prevented by 3-way in vitro fertilization?
A. Diseases that arise from mutations in the nuclear DNA
B. Diseases that arise from mutations in the mitochondrial DNA
C. Both
D. Neither
Question 8 1 point possible (graded) Which of these tissues are most likely to display significant defects in patients with a mitochondrial disease? (Select all that apply.)
A. Cartilage
B. Heart
C. Bone
D. Neural
E. Adipose
Question 9 0.0/2.0 points (graded) Barth Syndrome is characterized by dysfunctional mitochondria with a lower capacity to produce ATP. Barth syndrome patients experience difficulty walking and exercising. Why do Barth patients have these impairments? (Select all that apply.)
A. Because ATP is required for skeletal muscle contraction.
B. Because ATP is required for the pumping of blood by the heart.
C. Because ATP is required for the release of oxygen by red blood cells.
D. Because ATP is required for absorbing oxygen by red blood cells.
Question 10 0.0/2.0 points (graded) Bongkrekic acid is a mitochondrial toxin produced by bacteria in fermented coconuts. It blocks the inner membrane protein responsible for transporting ATP from the mitochondrial matrix to the cytosol. Bongkrekic acid also inhibits ADP import from the cytosol into the matrix for phosphorylation. Which of the following will occur in a cell exposed to bongkrekic acid? (Select all that apply.)
A. Most ATP in the cell will be produced by glycolysis because the mitochondria are inhibited.
B. The mitochondrial membrane potential will decrease due to decreased ETC proton pumping.
C. Respiration will decrease because the ATP synthase will lack ADP as the reactant.
D. Mitochondrial ATP levels will decrease.

Explanation / Answer

Question. 5

Ans - (i) increase (ii) decrease (iii) decrease

Question. 6

Ans - Mitochondrial DNA

Question. 7

Ans - Diseases that arise from mutations in the mitochondrial DNA

Question. 8

Ans - Heart

Question.9

Ans - Because ATP is required for skeleton muscle contraction

Question.10

Ans - Most ATP in the cell will bhi produced by glycolysis because the mitochondria are inhibited

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