Which of the following conditions is NOT associated with (or mediated by) comple

Question

Which of the following conditions is NOT associated with (or mediated by) complement activation? A. Paroxysmal nocturnal hemoglobinuria (PNH) B. Paroxysmal cold hemoglobinuria (PCH) C. Hemolytic disease of the newborn (HDN) due to anti-Rh(D) antibodies D. Drug-induced immune hemolysis via immune complex formation Direct antiglobulin test (DAT) (or Direct Coombs test) is positive in: A. Warm autoimmune hemolytic anemia B. Acute hemolytic transfusion reaction C. Drug-induced (e.g, methyldopa) hemolysis D. All the above

Explanation / Answer

For the first question, the answer is a option C) Hemolytic disease of newborn (HDN) due to Rh(D). Which is a condition not associated with complement activations. This condition is due to the maternal antibodies against the infants rhesus factor, results in destruction of infants RBCs.

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