10. The ________________ pathway involves the assembly of a nucleotide from PRPP

ID: 274191 • Letter: 1

Question

10. The ________________ pathway involves the assembly of a nucleotide from PRPP and a nucleobase.

11. In the de novo pyrimidine biosynthesis pathway, the initial nucleotide formed is ________________.

12. This type of topoisomerase can change the linking number (number of supercoils) of supercoiled DNA by 2 (?L = ±2): ________________.

13. UV light can cause damage to DNA by forming ________________.

14. The creation of a(n) ________________ site is required in the first step of the Base Excision Repair (BER) pathway.

15. _________________ are intermediates in recombination pathways and are composed of four polynucleotide chains in a cross-like structure. 1

6. The low-fidelity ________________ polymerases are employed in the SOS response.

17. A(n) _________________ is a sequence of DNA that codes for the specific enzymes necessary to insert itself into the recipient DNA.

18. In order to determine where transcription begins, RNA polymerase must specifically bind to the ________________ region of the DNA template.

Answer:

10. The De Novo pathway involves the assembly of a nucleotide from PRPP and a nucleobase.

11. In the de novo pyrimidine biosynthesis pathway, the initial nucleotide formed is UMP.

12. This type of topoisomerase can change the linking number (number of supercoils) of supercoiled DNA by 2 (?L = ±2): Type 2 topoisomerases

13. UV light can cause damage to DNA by forming Pyrimidines dimer (Thymine dimer).

14. The creation of a(n) AP site is required in the first step of the Base Excision Repair (BER) pathway.

15. Holliday Junctions are intermediates in recombination pathways and are composed of four polynucleotide chains in a cross-like structure.

6. The low-fidelity DNA polymerases are employed in the SOS response.

17. A(n) Insertion Sequence is a sequence of DNA that codes for the specific enzymes necessary to insert itself into the recipient DNA.

18. In order to determine where transcription begins, RNA polymerase must specifically bind to the promoter region of the DNA template.

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