?-islet cells always express the INS gene to some degree, but after a large meal

Question

?-islet cells always express the INS gene to some degree, but after a large meal, glucose levels in the blood rise and increased levels of insulin are required to stimulate cells to take up this glucose and convert it into energy. Which of the following events is likely to occur at the regulatory region of INS in response to increases in glucose in the blood stream?

decreased levels of H3K4 methylation ( incorrect )

increased levels of DNA methylation

binding of repressive proteins

binding of activating proteins

Explanation / Answer

The correct option is bindng of activating proteins. The activating proteins have two domains-activation domain and DNA binding domain.The activating proteins will recruit transcription factors that will then initiate the transciption of the INS gene.

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