Fragile X is a genetic based disease condition exhibits an unusual property. Whe

Question

Fragile X is a genetic based disease condition exhibits an unusual property. When the mutant form of the gene is compared to the wild type allele it is clear that the mutant has an excessive stretch of CpGpG trinucleotides in a long tandem repeat. Surprisingly, the additional repeats are not even in a coding region for the polypeptide derived from this gene. The actual problem results from the fact that: a. the mRNA is now excessively long. b. a frameshift occurs in the protein. c. the gene is converted to heterochromatin. d. CpG is a potential regulatory sequence in eukaryotes and thus impacts gene expression. e. the mRNA is blocked from being polyAdenylated and transported from the nucleus.

Explanation / Answer

Fragile X is a genetic based disease condition exhibits an unusual property. When the mutant form of the gene is compared to the wild type allele it is clear that the mutant has an excessive stretch of CpGpG trinucleotides in a long tandem repeat. Surprisingly, the additional repeats are not even in a coding region for the polypeptide derived from this gene. The actual problem results from the fact that:

a. the mRNA is now excessively long.

b. a frameshift occurs in the protein.

c. the gene is converted to heterochromatin.

d. CpG is a potential regulatory sequence in eukaryotes and thus impacts gene expression.

e. the mRNA is blocked from being polyAdenylated and transported from the nucleus.

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