Is a mouse actually a good model? please use the below info and explain why do w

Question

Is a mouse actually a good model? please use the below info and explain why do we still use mouses for models ? What other model would you pick

-more than 80% of potential therapies tested in mice models fail when tested on people -difficult to find a model that approximates same conditions that appear in humans, e.g. SIVcpz/HIV? -some of the animal models die during studies for reasons that have nothing to do with the therapy -studies fail to include both male and female mice -mice models are genetically uniform; necessary for statistical analyses but does not represent a disease affecting a genetically diverse population -’knock’ procedures & crosses need to ensure gene being studied is still there; it can be lost during breeding to produce enough of model organisms

Explanation / Answer

Humans and mice share many common genetic features and by examining the physiology, anatomy and metabolism of a mouse, scientists can gain a valuable insight into how humans function In the early days of biomedical research, scientists developed mouse models by selecting and breeding specific mice to produce offspring with certain desired characteristics.

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