Which of the following statements about antiplatelets is TRUE? Answers A-E A Dab

Question

Which of the following statements about antiplatelets is TRUE? Answers A-E A Dabigatrin is known as a double prodrug since the parent compound is metabolized into an active substance (dabigatran) and then dabigatran is further metabolized to active metabolites. B Clopidogrel is an irreversible inhibitor of the ADP receptor c Aspirin can inhibit the synthesis of both prostacyclin and Thromboxane A2. D Eptifibatide is a glycoprotein llb/llla receptor inhibitor E Actually, all of the above statements are true.

Explanation / Answer

A.Dabigatrin is known as double prodrug since the parent compoundis metabolozed into an active substance(diabatran)and then diabatran is further metabolized to active metabolites-TRUE

It is a directthrombin inhibitor,and functions by directly inhibiting both free and fibrin-bound thrombin.

Dabigatrin is considered a "reversible" antigoagulant medication.

dabigtrin etexilate is an inactive prodrug that is converted rapidly to the direct thrombin inhibitor dabigatran after oral administration.

B.Clopidogrel is an irreversible inhibitor of the ADP receptor-TRUE

The antiplatelet effect of the thienopyridine,clopidogrel,results from antagonism of a platelet ADP receptor ,P2T,resulting in inhibition of platelet activation.This antagonism is non-competitive,irreversible and results in a 50%-70% inhibition of platelet fibrinogen binding.Additionally,Clopidogrel may also antagonise the ADP-induced inhibition of adenylate cyclase,possibly resulting in an eleveted platelet cyclic adenosine monophosphate level after stimulation by an appropriate agonist such as prostacyclin.

C.Aspirin can inhibit the synthesis of both prostacyclin and Thromboxane A2-TRUE

Prostacyclin and Thromboxane A2 are products of arachidonic acid which play a role in the regulation of haemostatic plug and thrombus formation.Aspirin inhibits the synthesis of both compounds but it more active in blocking TXA2 formation,based on this,aspirin is suggested to have an anti-thrombotic effect.

D.Eptifibatide,isa glycoprotein llb/lla receptor inhibitor-TRUE

In medicine,glycoprotein llb/lla inhibitors,also Gpllb/lla inhibitors,is a class of antiplatelet agents.

Several Gpllb/lla inhibitors exist:

E.So the correct answer for the above is,E.(all of the above statements are TRUE).

Related Questions

Navigate

• Browse (All)
• Browse W
• Subjects

---

---

Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.