Describe how marijuana could lead to an increase in the firing of pyramidal cell

Question

Describe how marijuana could lead to an increase in the firing of pyramidal cells.

Retrograde Signaling by Endocannabinoids 1, Endocannabinoids are released from the pyramidal cell in response to depolarization Pyramidal uron CB receptor G protein GABA o to 2. They cross the synaptic cleft. Ca2+ ???" receptor Synaptic vesicles 3. They activate CB1 receptors on the axon terminals (presynaptic) of GABAergic cells GABA receptor GABA 4. They inhibit GABA release 5. Without inhibition, the pyramidal cell can fire more

Explanation / Answer

Marijuana is a drug that is both useful and harmful at the same time. It impacts the brain and as soon as someone takes marijuana or smokes it, the endocannabinoids are released from the pyramidal cell due to the depolarization. This leads to crossing of the endocannabinoids via the synaptic cleft. This leads to activation of the CB1 receptors on the axon terminals present in the GABAergic cells. This leads to inhibition of release of GABA and this causes the firing of the pyramidal cell.

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