Question 1: CDK inhibitors In a laboratory mutants have been identified in CDK4.

Question

Question 1: CDK inhibitors

In a laboratory mutants have been identified in CDK4.

Mutant A shows deletion of the kinase domain of Cdk4.

• Mutant B shows no degradation of Cyclin D1 by Cdk4.

Relative to the wild-type cells, which of these mutants (choose from mutant A or B) will show no cell proliferation? Explain why you selected this option over the other.

Q 2: How can chromatin remodeling influence gene expression? Explain with a specific example. Can it be inherited into daughter cells? Give example and mechanism..

Q3: Calcium, IP3, and cyclic AMP are all small molecules that can be found inside most cells, yet they are known to be important second messengers that can increase or decrease in response to a wide variety of signals. However, each signal often produces completely different responses. Give an example of this phenomenon, and explain how such responses occur.

Q4. What are some post translational modifications that govern Gene expression and Cell signaling.

Give several examples of the role ubiquitination plays in the same.

Explanation / Answer

Q.1

The mutant B will show no cell proliferation. This is because the mutation in kinase domain always leads to tumor formation so that the mutant in which there is no degradation of the cyclin D will show no proliferation, as CDK and cyclin D will not be able to make complex.

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