The opposite of transversion mutations are transition mutations. A transition mu

Question

The opposite of transversion mutations are transition mutations. A transition mutation happens when one purine is swapped with the other purine or a pyrimidine with pyrimidine. Purine Purine Pyrimidine Pyrimidine GAC?AAC GAC ? GAT Use the DNA code below to demonstrate a purine purine transition mutation. All you have to do is change one DNA base. Write each codon per line and circle the mutated amino acid. Original DNA TAC GTC GCT CAA CGG GAC CTG ACC ACT Transition DNA Mutated mRNAL Mutated Amino AcidEIRE Original Amino Acid Met Gln Arg Val Ala Leu Asp Trp STOP

Explanation / Answer

Original DNA: 5' - TAC GTC GCT CAA CGG GAC CTG ACC ACT - 3'
Transition DNA: 5' - TAC GTC GCT TAA CGG GAC CTG ACC ACT - 3'
Mutated mRNA: 5' - AUG CAG CGA AUU GCC CUG GAC UGG UGA - 3'
Mutated Amino Acid: Met Gln Arg Ile Ala Leu Asp Trp STOP
Original Amino Acid: Met Gln Arg Val Ala Leu Asp Trp STOP

The Transition DNA can be obtained by changing any one A to a G, G to an A, C to a T, or T to a C. This change itself is referred to as a Transition, since the purines are changing into other purines while the pyrimidines are changing into the other pyrimidine.
The mutated mRNA is obtained by writing down the stretch of nucleotides complementary to this strand of transition DNA, with once exception that mRNA contains Uracil (U) in the place of Thymine (T).
Hence, A to a U, G to a C, C to a G, and T to an A.

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