Is phosphoglucomutase likely to be regulated? Why or why not? What about glucose
ID: 270822 • Letter: I
Question
Is phosphoglucomutase likely to be regulated? Why or why not? What about glucose 6-phosphate dehydrogenase? Please write your answer below. You must submit an answer to see any explanation.Please write your answer below. Think critically as you craft your response, but note that there are many correct answers! You must submit an answer to see any explanation. Is phosphoglucomutase likely to be regulated? Why or why not? What about glucose 6-phosphate dehydrogenase? Please write your answer below. You must submit an answer to see any explanation.
Please write your answer below. Think critically as you craft your response, but note that there are many correct answers! You must submit an answer to see any explanation. Is phosphoglucomutase likely to be regulated? Why or why not? What about glucose 6-phosphate dehydrogenase? Please write your answer below. You must submit an answer to see any explanation.
Please write your answer below. Think critically as you craft your response, but note that there are many correct answers! You must submit an answer to see any explanation.
Explanation / Answer
Yes, phosphoglucomutase (PGM) is regulated with th help of p21- activated kinase 1 (Pak-1). The binding of this kinase, phophorylates and increases the activity of the PGM.
Glucose-6-phosphate-dehydrogenase (G6PD) is considered as a rate limiting enzyme in the pentose phosphate pathway. It converts Glucose 6-phophate to 6-phosphoglucono- lactone. The substrate G6P increases the action of the enzyme G6PD. Also, increase in the utilization of NADPH gradually increases lthe level of NADP+. This stimulates the production of NADPH by G6PD. Long chain fatty acids stimulate the action of yeast G6PD. Acetylation on lysine, negatively regulate G6PD. Also, regulation of G6PD may occur through genetic pathways and transcription factor HIF-1.
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