20. Which of the following is FALSE regarding the antibody-mediated response? a.
ID: 268849 • Letter: 2
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20. Which of the following is FALSE regarding the antibody-mediated response? a. B cell activation is involved. b. It is most effective against viral and intracellular pathogens. c. Plasma cells actively secrete antibodies 261 318 e. It often recruits the complement system [after antibodies have bound antigen]. 347 21. Activation of the complement system can cause direct lysis of the invading microbe due to a. inflammation d. interaction with antibodies c. phagocytosis b. opsonization e. formation of a membrane attack complex 410 Questions 22-24. Match the immunoglobulin to its main function or characteristic. 22. IgM 23. IgG 24. IgD a. found on surface of B cells and act as B cell receptors b. involved in allergic reactions c. found in milk, saliva, and on mucous membranes secreted as a dimer d, accounts for 75% of all immunoglobulins circulating in the blood, secreted as a monomer e. large pentamer that is the 'first responder' binding lots of antigen These immune cells contain CD8 glycoprotein receptors on their surface and interact with MHC I protein. They directly kill cancer cells and virally infected cells. a. helper T cells b. plasma cells c. cytotoxic T cells d. B cells e. antigen presenting cells 26. Theoretically, any nucleated cell of your body could alert the specific immune sy antigen processing is random, potentially causing invaders to go undetected? a. Fusion of phagosome and lysosome is blocked b. Antigen presenting cell cannot adhere to the microbe. c. Membrane vesicles containing MHC I may not be packaged in the same vesicle as endogenous antigens. d. Complement system is not stimulated by antibodies binding to antigen. e. Endogenous antigen processing is not a random process. None of these answers fit. system of an invader. Which step in endogenous 27. Endogenous antigen processing is generallyinvolving MHC I protein andcells. a, antiviral //? b, antibacterial // ? c. antibacterial // Tc d. antiviral //TH e. antiviral /I Tc 28. Mark the characteristic that applies to plasma cells. a. are made during clonal selection of T cells d. make lots of antibodies b. live a life time e. contain CD4 receptors c. act as antigen presenting cellsExplanation / Answer
20. b is false as the humoral response is most active against extracellular pathogens not intracellular and viral pathogens which are attacked by the cellular immune response such as lymphocytes.
21. e is correct, complementation pathway results in the formation of membrane attack complex made up of activated complement proteins which result in lysis of pathogen.
22. e is correct IgM is a large antibody it is a pentamer.
23. d is correct, it is most abundant immunoglobulin in the human body
24. a is correct IgD is expressed as a surface receptor on B cells.
25. c is correct cytotoxic T cells contains CD8 glycoprotein receptors
26. a is correct fusion of lysosome and phagosome is blocked.
27. c is correct, it is initiated by forming an endogenous vesicle interacting with MHC-I and CD8 cells
28. option c and d are only correct for plasma cells.
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