a.) Suppose you conduct a Genome-wide association study and identify alleles of
ID: 268406 • Letter: A
Question
a.) Suppose you conduct a Genome-wide association study and identify alleles of 12 genes that are associated with increased risk for Sudden Infant Death Syndrome (SIDS). You then develop a screening method to test before implementing an infant screening program? Do you think screening for SIDS risk based af GWAS results is a good idea? Should such screening be strongly recommended or mandatory? Defend your position. genomes of newborns for these 12 alleles. What issues should you consider bWhat kinds of diseases or conditions may be treatable with gene therapy? What are some of the problems encountered in early gene therapy trials and how might these be overcome? How is somatic gene therapy different from er line gene therapy? What are some of the ethical concerns vil with gene therapy? When do you feel gene therapy would be appropriate?Explanation / Answer
b, By gene therapy, many genetic disorders can be treated including haemophilia, SCID, cancer, neurodegenerative disorder, etc.
Somatic therapy will changes or replaces genes in person who gets affected with disease, means the offspring will not get affected by the therapy. But in turn, by germ therapy the effects of the treatment will be reflected with their offsprings because this therapy will cure only sex linked diseases, since the treatment targets sperm or eggs.
Germ line therapy has many controversies. Since it affects future generations by its treatment, the unborn fetus will have affected with the same genetic disorder which their parents had. Their children will have long time side effects with the therapy so because of this ethical issue, funds for the germ line gene therapy has also been stopped in US
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