Question 10 1 pts 12 Which of the following is TRUE about \"Intrinsic apoptosis

Question

Question 10 1 pts 12 Which of the following is TRUE about "Intrinsic apoptosis pathway"? Cell surface receptor recognizes extracellular signal and triggers the assembly of apoptosome to activate caspases. OA failure in mitochondrial potential induces a dramatic increase in cytosolic Ca2+ concentration, which leads to the denaturation of cellular proteins O A failure to repair DNA double strand break induces p53 phosphorylation and degradation of p53, which leads to the activation of caspases. O Protein complexes on mitochondrial membrane induces the leakage of cytochrome C which eventually activates caspases.

Explanation / Answer

The correct options are "protein complexes on mitochondrial membrane induces the leakage of cytochrome C, which eventually activates caspases." Select this option if only one answer is to be opted.

and " a failure to repair DNA double strand break induces p53 phosphoylation and degradation of p53, which leads to activation of caspases. ((Select this also if two answers can be opted)

Intrinsic pathway for apoptosis is triggered when the DNA is damaged beyond repair. Certain proteins called BH3 activate the mitochondria to become more permeable. It results in mitochondrial outer membrane permeability increase...leads to escape of cytochrome C into cytoplasm. This forms the apoptosome. Apoptosome activates the caspases which finally results in apoptosis.

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