1. You\'re studying cellular signaling through G-Protein Coupled Receptors (GPCR

Question

1. You're studying cellular signaling through G-Protein Coupled Receptors (GPCRs). Specifically you're working on a pair of newly identified GPCRs, GPCR-X and GPCR-Y. Each binds the same small ligand, but activates different heterotrimeric G-proteins that act on the effector protein, adenylyl cyclase. You have access to cells that express GPCR-X and NOT GPCR-Y, and other cells that express GPCR-Y and NOT GPCR-X You and your grad student mentor find that the binding of ligand has opposite effects on adenylyl cyclase activity for each cell type. GPCR-X activation causes an increase in adenylyl cyclase activity, while GPCR-Y activation causes a decrease in adenylyl cyclase. activity. A. (3pts) What can you and your grad student mentor measure experimentally to examine adenylyl cyclase activity upon treatment with ligand? B. (3pts) Based on the above stated effects on adenylyl cyclase activity, what type of G-protein is activated by each receptor?

Explanation / Answer

Solution:

1. Intracellular cyclic AMP

2. Heterotrimeric G proteins

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