2) The RNA World Hypothesis proposes that RNA was the initial carrier of genetic

Question

2) The RNA World Hypothesis proposes that RNA was the initial carrier of genetic information and cátalyzed reactions in primitive cells. Now, DNA and proteins have assumed those respective roles (for the most part). Why does RNA no longer have this role? a) b) c) d) e) RNA is far too stable. The single-stranded nature of RNA means replication is not conservative (highly mutable). The tertiary structure of RNA makes the RNA unstable and unable to carry genetic information. Because Francis Crick's Central Dogma says so. RNA is too unstable to catalyze any reactions, so proteins now conduct these roles. 3) Consider a weak acid in a solution with a pH of 6.0. Which of the following statements is true? a) The weak acid is a proton acceptor b) The weak acid has a lower affinity for its proton than does a strong acid. c) The [H+] is 10-6 M. d) At its pKa, the weak acid will be totally dissociated. e) All of the above are true.

Explanation / Answer

1) Option 'c' is the correct answer.

DNA replicates with more fidelity because on average there occurs only one mistake per every 109 & 1010 bases than RNA causing the RNA replication to be highly mutable. The single-stranded nature of RNA means that the replication of RNA is not semi-conservative.

2) Option 'e' is the correct answer.

An acid by it's definition itself is a proton donor, however in a weak acid, the affinity for proton is considerably lower from that of strong acid. The pH is the negative of the logarithmic concentration of H+ ions, hence for a pH of 6.0, the [H+] will be 10-6.

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