A particular protein sequence has the normal amino acid sequence of arginine-lys

Question

A particular protein sequence has the normal amino acid sequence of arginine-lysine-serine. A point mutation occurs in the template (=coding) strand of the DNA and the sequence changes to arginine-asparagine-serine. Use the genetic code below to determine which nucleotide in the template strand of DNA experienced the point mutation, and which base was changed.

G to C at the 2nd codon at the 3rd base
   A to T at the 1st codon at the 1st base
   T to A at the 2nd codon at the 3rd base
   G to C at the 3rd codon at the 1st base
   C to G at the 3rd codon at the 2nd base

UGUcys UUU phenyl UUC alanine UGC Cysteine UGA stop UGG truptophan UAC tgrosine UCC UCA serine UCG UUA 1eucine UUG UAAstop UAG CUU CUC CUA CUG CGU CAC stidine CGC CCU CAU CCA Proline CCG leucine CGA arginine CAA CAGglutamine CGG AUU AUC isoleucine ACC AUA AGU asparagine lAGC ACU Serine AAC threonine ACG AUG methionine AAG Iysine AGG arginine GUU GUC GUA Yaline GUG GCU GCC GCA alanine GCG GAU aspartic GGU GAC acid GGC GGA 9lycine GAA glutamic GGG GAG acid

Explanation / Answer

In the question, point mutation has changed lysine to asparagine. Thus mutation is in 2nd codon.

The coding strand sequence for lysine is AAG or AAA, and that for asparagine is AAT or AAC. This means , this is a A to T or G to C mutation.

Ans:

thus mutation is at 3rd position .

G to C at the 2nd codon at the 3rd base.

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