You are conducting a study to quantify copy number variations (CNVs) in the geno

Question

You are conducting a study to quantify copy number variations (CNVs) in the genomes of cancer patients. You use CGH to obtain hybridization signals for each sample. In one sample you see an increase in signal at one location that is 24x higher than the majority of the signal that you see in the rest of the genome. What does this imply about the copy number of the sequence at that location and the variation that occurred?

A. The CGH results are erroneous. B. There was a 24x increase in copy number, but the location of the extra copies in the genome is unknown. C. There was a 12x increase in copy number with new copies at that location in the genome. D. There was a 48x increase in copy number with new copies at that location in the genome. E. There was a 24x increase in copy number with new copies at that location in the genome.

Explanation / Answer

Right answer is E There was a 24x increase in copy number with new copies at that location in the genome.

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