iv) 14. Ebola virus infections are highly lethal, with some outbreaks displaying

Question

iv) 14. Ebola virus infections are highly lethal, with some outbreaks displaying fatality ra es of>85%. Currently, there are no approved treatments or vaccines for this filovirus, and the exact animal reservoir of Ebola virus is unknown. Briefly describe 1) the viral factors and 2) the host factors that contribute to this lethal pathogenesis in humans. 15. It is estimated that Dengue virus is responsible for ~22,000 annual deaths worldwide. Yet, there is no effective vaccine against this arthropod-borne virus. There are four serotypes of dengue virus. Infection by an individual serotype conveys protection against re-infection by that same serotype. Unfortunately, a second infection by a different serotype can result in a more pronounced and pathogenic infection, including Dengue nss) lso known as hreakhone

Explanation / Answer

14. 1  

The Ebola virus viral proteins include two nucleoproteins viz VP35 and VP24 and glycoproteins of Ebola virus by attacking the type I and II interferons.

14.2

The Ebola virus attacks the macrophages and dendritic immune cells of the host to cause the pathogenesis. Ebola virus is lethal because they affect the numerous number of tissue like spleen, kindneys, liver.

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