Please answer Q 119, 120, and 121 ??? K101-FinalExamStudyGuideTop200,SP18 (1) [C

Question

Please answer Q 119, 120, and 121

??? K101-FinalExamStudyGuideTop200,SP18 (1) [Compatibility Mode] Q- Search in Document Home Insert Design Layout References Mailings Review View tShare A Times New Ro...10 A- AAa Paste Heading1Heading 2 Heading 3 Heading 4 Huading 5 Headng 8 Heading ? 15 e. DNA polymerase 119.Match the mAb (monoclonal Antibody) drug with the disease it is intended to treat a. Herceptin b. Rituxin c. Enbrel d. Synagis e. Avastin (1) RSV (Respiratory syncytial Virus (2) Cancer (anti-VEGF, anti angiogenesis) (3) HER-2+ breast cancer (4) CD20+ Non-Hodgkins Lymphoma (5) T-cell autoimmune diseases like Rheumatoid arthritis and Psoriasis 120.Gene Therapy treatments with new drugs like Kymriah and Yescarta (select all that apply) a. b. c. d. e. Provide a safer bone marrow transplant procedure using matched donors Are the first FDA-approved drugs for personalized immunotherapy to treat specific leukemias Involve the use of a genetically engineered Chimeric Antigen Receptor T-cell to recognize proteins like CD19 on cancer cells Require the formation of a blastocyst that is then used for gene editing Can cure autoimmune disprders like diabetes and nultiple sclerosis 121.Match the following compoments of the CRISPR Cas9 Gene Editing system to their function a. PAM b. Cas9 C. sgRNA (1) An endonuclease that can create double strand breaks in DNA (2) An RNA molecule engineered to be complementary to the target to be edited (3) A 3-6 nucleotide DNA sequence immediately downstream of the target site in the genomic DNA to be edited 122.Which of these statements is NOT TRUE regarding the procedure for making cloned animals by somatic cell nuclear transfer? a. The recipient egg is e-nucleated before the procedure b. The donor nucleus can be either from a male or a female cell c. The donor nucleus is from a haploid, quiescent cell d. A brief electric shock is used to simulate fertilization e. A surrogate mother is used to carry the pregnancy to term 14 Page 14 of 25 11179 Words English (US) + 222%

Explanation / Answer

Ans. 119  

A. 3 her 2 breast cancer

B. 4 CD 20 +non Hodgkin lymphoma

C.5

D. 1

E. 2

Ans. 121

A. 3

B. 1

C. 2

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